纳米糊精微球对头孢曲松钠的吸附及其释药性能

Characteristics of dextrin nano-microsphere in adsorbing and releasing ceftriaxone sodium

以糊精为原料,三偏磷酸钠为交联剂,利用反相微乳液法制备糊精纳米微球,并对头孢曲松钠的吸附载药和释药性能进行了研究。为模拟人体血液环境,选取了pH 7.4的磷酸二氢钠-磷酸氢二钠缓冲液为介质考查了糊精微球的吸附载药及降解性能。实验表明,纳米糊精微球对头孢曲松钠的载药率为9.44%,载药能力随着投药量的增加而增加,温度对载药能力的影响不显著,在α-淀粉酶存在的条件下,降解6 h后有23.94%的纳米糊精微球被降解。

Dextrin nano microsphere （DNM） was prepared using dextrin as the raw material and Na3P309 as linking agent with inverse microemulsion. A buffer of DSP-MSP at pH 7.4 was chosen to simulate the blood environment and the adsorbing and releasing capability of DNM to ceftriaxone sodium was studied. The results showed that the capability of DNM adsorbing ceftriaxone sodium was 9.44%. The adsorbability was increased as the increasing ceftriaxone sodium input with little effect from the temperature. The 23.94%. DNM was degraded after treatment with α-amylase for 6 h.