期刊文献+

胰岛素抵抗与妊高征发病及围产儿预后的关系 被引量:4

The Relationship of Insulin Resistance and the Pathogenesis and Perinatal Outcome of Pregnancy Induced Hypertension
原文传递
导出
摘要 目的探讨胰岛素抵抗与妊高征发病及围产儿预后的关系。方法选择妊高征孕妇111例为妊高征组,正常妊娠妇女155例为对照组;分别于孕32周前和32周后取母血,分娩后取脐血,测定胰岛素和C肽浓度;比较新生儿出生体重、Apgar评分和羊水状况。结果妊高征组C肽和胰岛素的浓度在孕32周前、后均明显高于对照组(P<0.001和P<0.01)。在妊高征组,宫内发育迟缓、新生儿窒息和羊水异常时,母儿C肽和胰岛素浓度均有上升的趋势,并且发生在妊娠32周之前;在对照组,宫内发育迟缓时,孕妇C肽和胰岛素浓度有下降的趋势。结论胰岛素抵抗在妊高征的发生、发展,以及围产儿预后不良等方面均有重要意义。 Objective To study the insulin resistance in the pathogenesis of pregnancy induced hypertension (PIH), and its relationship to perinatal outcome. Methods In 111 PIH and 155 control group, the concentration of C peptide and insulin of maternal blood samples before and after 32 gestational weeks, and fetal blood samples just after delivery was determined. Fetal outcomes were assessed by the neonatal weight at delivery, Apgar scores and the quality and quantity of amniotic fluid. Results The maternal concentration of C peptide and insulin in PIH was higher than that of control group( P <0.05,or P <0.01). In PIH group, the maternal concentration of C peptide and insulin in the subgroup of adverse perinatal outcomes tended to be higher than that in the subgroup of good perinatal outcomes; but in control group, there was no significantly difference between these two subgroups.Conclusions Insulin resistance may be one of the factors which couse PIH, and it has significant relationship with advese perinatal outcomes.
出处 《中华妇产科杂志》 CAS CSCD 北大核心 1998年第10期581-584,共4页 Chinese Journal of Obstetrics and Gynecology
基金 国家教委博士点基金
关键词 妊娠高血压 胰岛素抵抗 围产儿 预后 Pregnancy complications, cardiovascular Hypertension Insulin resistance Perinatology Prognosis
  • 相关文献

参考文献2

  • 1谈海英,中华妇产科杂志,1996年,31卷,600页
  • 2古航,中华妇产科杂志,1994年,29卷,711页

同被引文献27

  • 1李溥,岑荣光,宋扬秀,郑雷.妊娠期糖尿病患者胰岛素抵抗与细胞内钙离子浓度变化的关系[J].标记免疫分析与临床,2004,11(3):140-142. 被引量:4
  • 2McCance DR, Pettitt DJ, Hanson RL, et al. Birth weight and non insulin dependent diabetes: thirty genotype, thirty phenotype, or surviving small baby genotype? BMJ. 1994,308:942.
  • 3Phillips DIW. Insulin resistance as a programmed response to fetal under nutrition. Diabetologia. 1996, 39:1119.
  • 4Terallchi Y, Kubota N, Tamemoto H, et al. Insulin effect during embryogenesis determines fetal growth. Diabetes. 2000,49:82.
  • 5Tamenmoto H, Kadonaki T, Tobe K, et al. Insulin resistance and growth retardation in mice lacking insulin receptor substrate - 1. Nature.1994,37:182.
  • 6Poulsen P, Waag AA, Kyvie KD, et al. Low birth weight is associated with NIDDM in discordant monozygotic and dizygotic twim pairs. Diabetoligia. 1997,40:439.
  • 7Hales CN, Barker DJP, Clark PMS, et al. Fetal and infant growth and impaired glucose tolerance at age. BMJ. 1991,303:1019.
  • 8Lindsay RS, Dabelea D, Roumain J, et al. Type 2 diabetes and low weight. Diabetes. 2000,49:445.
  • 9Desai M, Crowther NJ, Ozanne SE, et al. Adult glucose and lipid metabolism may be programmed during fetal life. Biochem Soc Trans.1995, 23:331.
  • 10Phillips D1W, Barker DJP, Fall CHO, et al. Elevated plasma cortisol contrations: a link between low birth weight and the insulin resistance syndrome? J Chin Endcrinol Metab. 1998, 83:757.

引证文献4

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部