胃肠道间质瘤的临床特征及外科诊治分析

The Clinical Characteristics of Gastrointestinal Stromal Tumor Patient about Surgical Diagnosis and Treatment

目的探讨胃肠道间质瘤的的临床特点及外科治疗经验。方法回顾性分析2000年1月至2008年6月手术治疗40例胃肠道间质瘤患者的临床资料。结果胃肠道间质瘤中位年龄56.7岁,主要发生于胃和小肠,主要临床表现为腹胀、腹痛和消化道出血。术前9例诊断为间质瘤,2例获得病理确诊;40例患者行根治性手术治疗,12例复发再次手术;4例高度恶性患者术后口服格列卫靶向药物治疗;平均随诊3.5年,其中4例死亡。结论间质瘤临床表现无明显特征性,术前确诊率低,综合分析有助于提高确诊率,目前手术切除是胃肠道间质瘤的首选治疗,分子靶向治疗将成为今后治疗的重要手段和发展方向。

Objective To study of gastrointestinal stromal tumors of the clinical features and surgical treatment. Methods Retrospective analysis in January 2000 to June 2008 in surgical treatment of 40 cases of gastrointestinal stromal tumors in patients with clinical data. Results Gastrointestinal stromal tumors a median age of 56.7 years, mainly in the stomach and small intestine, the main clinical manifestations were abdominal distension, abdominal pain and gastrointestinal bleeding. 9 patients with preoperative diagnosis of stromal tumor, 2 cases were confirmed by pathology; 40 patients underwent radical surgery, 12 patients with recurrent re-operation; 4 cases of high-grade postoperative oral targeted drug Gleevee treatment; mean follow-up 3.5 years, including 4 deaths. Conclusions Stromal tumors no significant characteristic clinical manifestation, preoperative diagnosis rate is low, a comprehensive analysis will help improve diagnosis rates, surgical resection is currently gastrointestinal stromal tumors of choice for treatment, molecular targeted therapy will become an important means of treatment and direction of development.