A群轮状病毒患儿肌酸磷酸激酶、超敏C反应蛋白等结果的变化

Serum Myocardial Enzymes and High Sensitivity C-reactive Protein Levels in Young Children with Rotavirus A Infection

目的检测腹泻患儿大便中的A群轮状病毒、血清心肌酶、超敏C反应蛋白(hs-CRP)及肠道菌群的变化。方法用免疫胶体金法检测患者大便中的A群轮状病毒、全自动生化仪检测其血清中的心肌酶、金标法测超敏C反应蛋白、并作肠道菌群分析,对照组采用同样方法测定。结果检测了234例腹泻患儿,其中124例A群轮状病毒抗原阳性,阳性患儿的血清心肌酶、超敏C反应蛋白明显高于正常对照组,有45例阳性患儿大便中检测到白色假丝酵母菌等真菌生长。结论A群轮状病毒引起婴幼儿胃肠道感染、导致肠道菌群失调,还会引起心肌的损伤,也可导致超敏C反应蛋白明显升高,对这些项目的检测有助于该病的诊断、治疗。

OBJECTIVE To detect the changes in young children, with diarrhea including rotavirus A antigens in stool specimens, serum myocardial enzymes, high-sensitivity C-reactive protein （hs-CRP） and alteration of intestinal flora. METHODS Rotavirus A antigens in stool specimens were detected by immunologic colloidal gold, serum myocardial enzymes were measured by full automatic analyzer, hs-CRP level of serum specimens was measured by gold labeled test, and alteration of intestinal flora was also analyzed. The same method was also applied in control group. RESULTS Among 234 diarrhear cases of young children, 124 cases with positive rotavirus A antigens appeared the high level of serum myocardial enzyme and hs-CRP compared with the control group. Candida a[bicans from stool specimens was detected in 45 cases with positive rotavirus A. CONCLUSIONS The results indicate that rotavirus A can cause gastrointestinal tract infection in young children, lead in alteration of intestinal flora,damage myocardium and lead to high level of hs-CRP. All these laboratory results are significant for clinical diagnosis and treatment.