重症监护病房铜绿假单胞菌的分布及耐药性分析

Distribution and Drug Resistance of Pseudomonas aeruginosa in ICU

目的探讨重症监护病房（ICU）铜绿假单胞菌（PAE）医院感染的标本分布及耐药性，为临床控制PAE医院感染提供依据。方法回顾性调查医院2005年1月～2008年12月ICUPAE感染的临床情况，对277株PAE的药敏试验结果进行统计分析。结果医院ICUPAE主要来源于呼吸道标本，占总数的56．0％。对头孢曲松、头孢噻肟、庆大霉素耐药率均〉64．0％，对其他抗菌药物也产生了不同的耐药性；而对亚胺培南、美罗培南、阿米帚星、头孢哌酮／舒巴坦、哌拉西林／他唑巴坦、左氧氟沙星敏感率均〉74．0％。结论临床医师应根据病原学检查的结果，合理使用抗菌药物，提高抗感染治疗水平。

OBJECTIVE To approach the distribution and drug resistance of Pseudomonas aeruginosa （PAE） in nosocomial infection in intensive care unit （ICU） and provide the evidence for clinical controlling of it. METHODS Clinical data of nosocomial infection with PAE isolated from ICU from Jan 2005 to Dec 2008 were investigated retrospectively. The results of susceptibility test in 277 PAE strains were analyzed statistically. RESULTS PAE strains were mostly isolated from respiratory tract （56.0%）. The drug resistance rates to ceftriaxone, eefotaxime and gentamicin were all above 64. 0%. PAE was resistant to the other antibiotics in different degrees. The suceptibility rates to imipenem, meropenem, amikacin, cefoperazone/sulbactam, piperacillin/tazobactam and levofloxacin were all above 74.0%. CONCLUSIONS The clinician should use the antibiotics reasonably according to etiological testing to elevate the level of anti-infection treatment.