尿路感染病原菌的耐药性调查分析

Drug Resistance of Pathogens Isolated from Urinary Tract

目的探讨尿路感染病原菌的分布特点及耐药性,为临床医师合理用药提供试验依据。方法218株尿路感染病原菌的分离鉴定按照《全国临床检验操作规程》,采用常规方法进行;采用CLSI推荐的K-B法进行药物敏感试验和评价结果。结果医院218株尿路感染病原菌中大肠埃希菌占第1位,为61.0%;肠球菌属第2位,占11.5%;尿路感染病原菌对常用抗菌药物均产生了一定的耐药性,但万古霉素、替考拉宁和亚胺培南、美罗培南分别对革兰阳性菌和革兰阴性菌100.0%敏感;产超广谱β-内酰胺酶(ESBLs)细菌检出率为32.9%。结论尿路感染病原菌耐药性不断增强,应加强监测与控制。

OBJECTIVE To approach the distribution characteristic and drug resistance status in pathogens from infected urinary tract in Jingshan County and offer the scientific evidence for clinically reasonable use of antibiotics. METHODS Totally 218 strains of pathogens isolated from urinary tract were identified by routine methods according to the National Clinical Laboratory Operation Rules. Drug susceptibility testing was performed by K-B methods recommended by CLSI. RESULTS Among 218 strains of pathogens from infected urinary tract, Escherichia coli accounted for 61.0%, ranking the first and enterococci ranked the second, accounted for 11. 5%. Except for 100% sensitivity to vancomycin and teieoplanin in Gram-positive bacteria and to imipenem and meropenem in Gram-negative bacteria, the pathogens from infected urinary tract had been resistant to commonly used antibiotics in some degrees. The detection rate of extended-spectrum beta-iactamases （ESBLs） producers was 32.9%. CONCLUSIONS The drug resistance in pathogens from infected urinary tract is on the rise. We should strengthen monitoring and controlling of it.