泌尿生殖道支原体感染的调查与药敏试验分析

Investigation and Antibiotic Analysis of Urogenital Mycoplasma Infection

目的分析非淋菌性尿道炎（NGU）患者支原体感染及药敏状况，为指导临床合理用药提供依据。方法对279例NGU患者泌尿生殖道分泌物进行支原体的培养、鉴定、计数及药敏试验，并对12种抗菌药物对支原体的敏感性进行回顾性统计分析。结果279例NGU患者检出支原体共162株，阳性率为58．1％；其中解脲脲支原体（Uu）阳性者115例（70．9％），人支原体（Mh）阳性者9例（5．6％），混合感染者38例（23．5％）；年龄分布以20～35岁的性活跃人群发病最高，约53．7％；支原体敏感性较好的药物是米诺环素、四环素，耐药率较高的是红霉素、司帕沙星。结论NGU患者的病原体主要是Uu，米诺环素、四环素町作为治疗支原体感染的首选药物，重视NGU的病原学检测和药敏试验，对指导临床用药，最大限度地控制耐药菌株的产生，尤为重要。

OBJECTIVE To analyze the of non-gonococcal urethritis （NGU） secretion in patients with urogenital mycoplasma infection and drug sensitivity status to provide the basis for clinical rational drug use. METHODS The mycoplasma culturing, identification, counting and drug sensitivity test to 12 kinds of antimicrobial drugs were conducted among 279 cases of NGU patients and the sensitivity of mycoplasma was monitored by retrospectively statistical analysis. RESULTS A total of 162 strains were isolated from 279 cases with NGU （58.1%）. Urea plasma urealyticum （Uu） was found in 115 cases （70.9%）, Mycoplasma hominis （Mh） positive in 9 cases （5.6%） and 38 cases were with mixed infection （23.5 %）. The sexually active population of 21-35-year-old was with the highest incidence, accounted for 53.7% from all of NGU cases. The sensitivity to minocycline, Tetracycline, of were higher but resistant to Erythromycin, sparfloxacin Mycoplasma. CONCLUSIONS Uu is the major pathogens in NGU patients, minocycline and tetracycline treatment for mycoplasma infection is better choice. The NGU pathogen detection and drug sensitivity test are important for guiding clinical treatment in order to maximize control of the emergence of resistant strains particularly important.