人乳头状瘤病毒DNA检测在宫颈病变筛查中的价值

Evaluation of HPV-DNA Test in Screening of Cervical Lesions

目的评价人乳头状瘤病毒DNA(HPV-DNA)检测在宫颈病变筛查中的价值。方法对宫颈病变的患者进行HPV-DNA检测,宫颈刮片,病理组织学检查,并以病理结果为金标准,对178例病理结果阳性(CINⅠ、CINⅡ、CINⅢ、宫颈浸润癌)的患者,比较HPV-DNA检测与宫颈刮片的敏感度;比较不同组织细胞学分类患者中HPV-DNA的检出率。结果病检178例阳性患者中,HPV-DNA检测敏感度为85.4%,宫颈刮片检测敏感度为50.6%,两者比较差异有统计学意义(P<0.01);HPV检测对诊断≥CINⅡ级宫颈病变差异有统计学意义(P<0.01)。结论HPV-DNA检测是防治宫颈癌较好的生物学指标,并根据病变的发展状态及时治疗。

OBJECTIVE To evaluate the value of HPV-DNA test in the screening of cerical lesions. METHODS Patients with cervical lesions were detected by HPV-DNA test Papanicolaou （Pap） smear and pathological inspection, and the pathological results were regarded as gold standard. From the 178 positive cases,we compared the sensitivity of HPV DNA test and Pap smear, and the HPV-DNA detection rate from patients with different histocytological classification. RESULTS All of 178 cases were positive in pathological inspection, the HPV-DNA test sensitivity was 85.4%, whereas Pap smear was 50. 60%, the difference between HPV-DNA test and Pap smear was significant （P〈0.01）. CONCLUSIONS HPV-DNA test is the better biology index to prevent and cure cervical cancer,and we can treat it in time according to the pathology result.