肿瘤患者苍白密螺旋体感染检测及流行特点分析

Examination of Antibody Against Treponema pallidum and Epidemical Characteristic Analysis among Tumor Patients

目的了解医院住院患者苍白密螺旋体(梅毒螺旋体,TP)感染状况及流行特征,有针对性地预防梅毒的医院感染。方法用酶联免疫吸附试验(ELISA)法对住院患者血清中梅毒抗体(TP-AB)进行测定,阳性结果进行双孔复检核实,并做Trust或TP明胶凝集试验(TPPA)的对比测试,最后做回顾性总结。结果TP-AB阳性总检出率为1.4%;Trust与ELISA的符合率为51.8%;ELISA与TPPA比较,其假阳性率为4.3%;肿瘤患者年龄越大阳性检出率越高,各年龄段阳性检出率差异有统计学意义(P<0.05);宫颈癌与泌尿系肿物患者阳性率最高,与其他部位(肝癌除外)的肿瘤比较,差异有统计学意义(P<0.05);城镇和城市患者感染率高于农村,工人和干部感染率高于农民。结论恶性肿瘤患者TP-AB阳性检出率较高,隐性梅毒较普遍,为了控制医院感染,梅毒筛查高年龄患者也不能忽视。

OBJECTIVE To understand the current situation and epidemical features of syphilis infections among patients in our hospital by the way of retrospective anlysis and provide scientific basis for control of syphilis infections in hospital. METHODS Anti-Treponema pallidurn （TP） antibody in patients＂ serum samples was detected with ELISA method. The positive results were compared with Trust and TPPA methods. RESULTS The positive rate of anti-TP was 1.4G in all patients. The identical positive results were 51.8% for Trust method and ELISA method. Compared with TPPA method, the false negative rate of anti-TP was 4.3% for ELISA method. The syphilis positive rate of the elderly was higher than youngers in tumor patients. There was a significant difference among age groups in syphilis infection （P〈0.05）. There was highest positive rate in cervical cancer and urological tumor patients. The positive rate was higher in city patients than that of rural ones. The positive rate of workers and cadres was higher than that of peasants. CONCLUSIONS There is a high positive rate of TP antibody in tumor patients. Latent syphilis is common. To the elderly patients should be paid special attention.