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阿尔茨海默病发病机制中突触病理及突触囊泡内吞蛋白的改变 被引量：8

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摘要 阿尔茨海默病（Alzheimer’s disease，AD）是常见于老年人的中枢神经系统退行性变疾病，以进行性认知功能障碍为主要临床表现。由β淀粉样肽（β-amyloid peptide，Aβ）沉积形成的老年斑（senile plaques，SP）、高度磷酸化Tau蛋白聚集形成的神经原纤维缠结（neurofibrllary tangles，NFTs）及神经元丢失构成AD脑组织中典型的神经病理学改变。
作者 曹颖 官志忠
机构地区 贵阳医学院病理教研室
出处 《中华老年心脑血管病杂志》 CAS 北大核心 2010年第1期92-94,共3页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金 国家自然科学基金(30870986) 贵州省科技厅基金[(2007)2087]
关键词 阿尔茨海默病 认知障碍 突触囊泡蛋白 突触 神经原纤维缠结
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献16

  • 1官志忠,齐晓岚.阿尔茨海默病的分子发病机制及其治疗研究进展[J].中华病理学杂志,2008,37(1):11-15. 被引量：38
  • 2Arendt T. Synaptie degeneration in Alzheimer's disease. Acta Neuropathol, 2009,118 : 167-179.
  • 3Lacor PN, Buniel MC, Furlow PW, et al. Aβ Oligomer-indueed aberrations in synapse composition, shape and density provide a moleeular basis for loss of connectivity in Alzheimer disease. J Neurosci, 2007,27 : 796-807.
  • 4Leuba G, Savioz A, Vernay A, et al. Differential changes in synaptie proteins in the Alzheimer frontal cortex with marked inerease in PSD-95 postsynaptic protein. J Alzheimer's Dis, 2008,15 : 139-151.
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  • 7陈贵海,尹世杰,周江宁.突触改变与Alzheimer病发病的关系[J].中华神经科杂志,2003,36(3):228-230. 被引量：5
  • 8Yao PJ,Zhu M,Pyun EI,et al. Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease. Neurobiol, 2003,12 : 97-109.
  • 9Kuwano R, Miyashita A, Arai H, et al. Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. Human Molecular Genetics, 2006, 15: 2170-2182.
  • 10Selkoe DJ. Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res, 2008, 192:106-113.

二级参考文献41

  • 1WANGQing-hua,XURu-xiang,SeigoNagao.Transplantation of cholinergic neural stem cells in a mouse model of (Alzheimer’s) disease[J].Chinese Medical Journal,2005(6):508-511. 被引量：20
  • 2Chan SL,Furukawa K,Mattson MP. Presenilins and APP in neuritic and synaptic plasticity: implications for the pathogenesis of Alzheimer's disease. Neuromolecular Med,2002,2:167-196.
  • 3Takahashi RH,Milner TA,Li F,et al. Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol,2002,161:1869-1879.
  • 4Masliah E,Alford M,DeTeresa R,et al. Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease. Ann Neurol,1996,40: 759-766.
  • 5Barger SW,Basile AS. Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. J Neurochem,2001,76: 846-854.
  • 6Victor M,Ropper AH,eds. Adam's and Victor's principles of neurology. 7th ed. New York: McGraw-Hill,2001. 1113-1115.
  • 7周江宁,刘荣玉. 老年性痴呆的非药物治疗.见:盛树力,主编. 老年性痴呆的治疗与护理. 北京:科学文献出版社,2000. 158-175.
  • 8Kandel ER,Schwartz JH,Jessell TM,eds. Principles of neural science. 4th ed. New York: McGraw-Hill,2001. 173-309.
  • 9Masliah E,Mallory M,Alford M,et al. Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease. Neurology,2001,56: 127-129.
  • 10Jahn R,Südhof TC. Membrane fusion and exocytosis. Annu Rev Biochem,1999,68: 863-911.

共引文献41

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中华老年心脑血管病杂志
2010年 第1期

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