摘要
目的:了解某院开放性骨折患者抗菌药物应用情况,为临床用药提供参考。方法:调查某院2007年开放性骨折病例1498例,对抗菌药物品种与应用频次、细菌培养结果、联合用药、用法用量、给药时间等进行统计、分析。结果:该院开放性骨折患者抗菌药物应用率达99.20%,应用品种以β-内酰胺类、氨基糖苷类和硝基咪唑类等为主。感染病例以革兰阴性菌为主,治疗用药以联合用药为主,预防用药以单一用药为主,存在预防性应用抗菌药物品种偏高、不合理联用、剂量过大、应用时间过长等问题。结论:该院开放性骨折患者抗菌药物应用尚存在诸多问题,亟需加强规范化管理。
OBJECTIVE： To investigate the status quo of used antibacterial drugs in patients with open fracture in order to provide reference for clinical medication. METHODS： 1 498 cases of open fracture in 2007 were analyzed statistically in respect of categories of antibiotic, application frequency of bacteria, result of bacteria culture, drug combination, usage and dosage and administration time, etc. RESULTS： In infection cases, patients were generally infected by Gram-negative bacteria and conducted drug combination for treatment and single drug for prevention. But some problems still occurred such as prophylactic use of antibiotics with high level, unreasonable drug combination, excessive dosage and long administration duration, etc. CONCLUSION： The ratio of antibacterial used in patients with open fracture reached up to 99.20%. The categories of used antibiotic were mainly β-1actam, aminoglycosides and nitroimidazoles. There are many problems in the use of antibiotics in patients with open fracture, which should be standardized in administration.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第2期115-117,共3页
China Pharmacy
