我院抗癫痫药血药浓度监测情况分析

Monitoring on Serum Concentrations of Anti-epileptic Drugs in Our Hospital

目的:为临床合理应用抗癫痫药提供参考。方法:采用回顾性方法,对我院2007年499例抗癫痫药治疗患者服用苯妥英钠、苯巴比妥、卡马西平和丙戊酸钠的血药浓度结果进行统计、分析。结果:单一用药患者中,血药浓度在正常治疗范围内者206例/次,占61.49%。联合用药患者中,血药浓度在正常治疗范围内者仅45例/次,占44.12%;服用中药治疗的患者中检出含有以上4种药物者占59.68%,服用中药治疗的患者中血药浓度在正常治疗范围内者占3.23%。结论:在应用抗癫痫药时,通过监测血药浓度,能更好地控制治疗浓度,避免多药联用,实现个体化给药。中药中是否含有化学合成药物成分也应引起重视。

OBJECTIVE： To provide reference for clinical rational use of anti-epileptic drugs. METHODS： In this retrospective review, serum concentrations of anti-epileptic drugs in a total of 499 patients who were treated with anti-epileptic drugs （such as sodium phenytoin, phenobarbital, carbamazepine and valproate sodium） in our hospital during 2007 were analyzed statistically. RESULTS： Among the patients receiving one kind of anti-epileptic drugs, 206 cases （61.49%） were within normal range in blood concentration versus only 45 cases （44.12%） for patients receiving combined drugs. In addition, the above four drugs （sodium phenytoin, phenobarbital, carbamazepine and valproate sodium） were detected in 59.68% of the patients who took Chinese medicines, and among them, 3.23% were within normal range in blood concentration. CONCLUSION： Monitoring on serum concentrations of anti-epileptic drugs is conducive to a better control of therapeutic concentration. It is advisable to refrain from using anti-epileptic drugs in combination but to adopt individualized administration. In addition, great importance should be attached to whether there are chemo-synthetic drug components contained in Chinese medicine.