鲑降钙素联合仙灵骨葆治疗绝经后妇女骨质疏松症所致骨痛疗效观察

Efficacy of Salmon Calcitonin plus Xianling Gubao for Osteoporosis and Ostealgia in Postmenopausal Women:A Clinical Observation

目的:观察鲑降钙素联合仙灵骨葆治疗绝经后妇女骨质疏松症所致骨痛的疗效及安全性。方法:160例绝经后骨质疏松症所致骨痛妇女随机分为3组,治疗组鼻喷鲑降钙素500IU每日1次,并口服仙灵骨葆胶囊1.5g,每日2次;对照组Ⅰ鼻喷鲑降钙素500IU,每日1次;对照组Ⅱ口服仙灵骨葆胶囊1.5g,每日2次。3组均口服钙尔奇D,每日1片。以30d为1疗程,连续使用3个疗程。评定3组骨痛性质和程度变化,记录药品不良反应发生情况。结果:治疗组、对照组Ⅰ、对照组Ⅱ的总有效率分别为92.59%、69.81%、67.92%,治疗组总有效率与对照组Ⅰ、对照组Ⅱ比较差异有统计学意义(P<0.05);不良反应发生率分别为18.52%、16.98%、11.32%,3组不良反应发生率差异无统计学意义(P>0.05)。结论:鲑降钙素联合仙灵骨葆治疗绝经后妇女骨质疏松症所致骨痛疗效确切,能有效增加患者骨密度,缓解骨质疏松症所致骨痛,是一种安全、有效的方法。

OBJECTIVE ： To evaluate the efficacy and safety of salmon calcitonin plus Xianling gubao for osteoporosis and ostealgia in postmenopausal women. METHODS： 160 women with postmenopausal osteoporosis and ostealgia were randomized to 3 groups （treatment group and 2 control groups）： the treatment group received（500 IU q.d） salmon calcitonin nasal spray plus Xianling gubao（1.5 g b.i.d orally）; the control group Ⅰ received（500 IU q.d） salmon calcitonin nasal spray alone and the control group Ⅱ received Xianling gubao（ 1.5 g b.i.d orally） alone. All the patients received oral Caltrate D （1 tablet q.d）. A course was defined as ,30 days. After treatment for a total of 3 courses, the nature and degree of ostealgia in all the patients were assessed, and the outcome indexes were measured and the adverse drug reactions were recorded. RESULTS： There were significant differences between the treatment group and two control groups in total effective rates（92.59% for treatment group vs. 69.81% for control group I and 67.92% for control group II, P〈0.05）; however, no significant differences were noted across the 3 groups in the incidences of adverse drug reactions （18.52%, 16.98% and 11.32%, respectively, P〉0.05）. CONCLUSION： Treatment of osteoporosis and ostealgia in postmenopausal women with salmon calcitonin plus Xianling gubao has been proved to be safe and effective in that the bone density can be increased effectively and the osteoporotic pain of lumbar and back of the patients can be relieved.