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GH—IGF-1与慢性肾脏病

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摘要 目前预防和治疗慢性肾脏病(CKD),主要是基于早期、积极治疗高血压和蛋白尿。其他一些治疗方法在不久的将来有可能被应用到临床。实验数据表明,生长因子(GH)可能对肾脏增长、疤痕形成以及慢性肾脏病的进展产生不利影响。基于抑制生长因子的疗法,有一定益处,但未能应用于慢性肾脏病临床。另一方面,一些小规模的研究报道,胰岛素样生长因子-1(IGF-1)对肾功能有相矛盾的影响。对于终末期肾病,生长激素已经在一些小规模研究中显示出能够减轻炎症,改善血脂水平,并对心血管参数有积极影响。研究还显示出给予IGF-1治疗对肾脏替代治疗患者营养参数的一些有益的影响。生长因子治疗可能有利于降低成人慢性血液透析(CHD)患者的发病率和死亡率。
出处 《国际泌尿系统杂志》 2010年第1期118-123,共6页 International Journal of Urology and Nephrology
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参考文献46

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