解毒活血方对萎缩性胃炎大鼠胃泌素含量的影响

Effect of Jiedu Huoxue Prescription on gastrin of atrophic gastritis rats

目的:观察解毒活血方对萎缩性胃炎大鼠胃泌素含量的影响。方法:用N-甲基-N’-硝基-N-亚硝基胍、水杨酸钠、热盐水、饥饱失常四因素法复制萎缩性胃炎大鼠模型,放射免疫法检测血清胃泌素含量。结果:与模型组相比,解毒活血方组、三九胃泰组和维霉素组胃泌素含量均明显升高,具有统计学意义(P<0.01);解毒活血方组胃泌素含量明显高于三九胃泰组和维霉素组(P<0.01)。结论:提高胃泌素含量可能是解毒活血方治疗萎缩性胃炎的机制之一。

Objective： To observe the effect of Jiedu Huoxue Prescription on gastrin of atrophic gastritis rats. Methods： The atrophic gastritis rats model was established by using combination of MNNG, sodium salicylate, hot saline water and irregular diet. The blood serum gastrin content was detected with RI. Results： Compared with model group, the contents of gastrin in Jiedu Huoxue Prescription group, sanjiu group and weimeisu group increased significantly （P〈0.01）; the contents of gastrin in Jiedu Huoxue Prescription group, was obviously higher than that in sanjiu group and weimeisu group （P〈0.01）. Conclusion： To improve the content of gastrin may be one of the mechanism of Jiedu Huoxue Prescription to treatment the atrophic gastritis.