吗啡和甲硫脑啡肽在应激性胃粘膜损害中的作用

EFFECTS OF MOPHINE AND METHIONINE-ENKEPHALIN ON STRESS-INDUCED GASTRIC INJURY

研究了吗啡和甲硫脑啡肽对束缚+寒冷刺激引起的大鼠应激性胃粘膜损害的影响。结果表明:外周静脉注射吗啡和甲硫脑啡肽均能降低应激性胃粘膜损害指数,但甲硫脑啡肽的作用较吗啡为弱。纳洛酮能部分地翻转吗啡和甲硫脑啡呔的抑制效应。提示,吗啡和甲硫脑啡肽能减轻应激性胃粘膜损害的程度,其作用与阿片受体有关。

The role of morphine and Methionine-enkephalin in gastric mucosal injury induced by stress was studied.Rats were tied on a meshed board and exposed to cold(4±0.5℃)for 3 hours. Results showed that both morphine and Met-enkephalin(iv)reduced the iudex of gastric mucosal injury induced by stress,morphine being more effective.Their actions can be partly reversed by naloxoae.It is suggested that gastric mucosal injury induced by stress might be lightened by morphine or Met-enkephalin Via opiate receptors.