应用国产哌吡酮治疗十二指肠溃疡的近期疗效观察

OBSERVATION OF SHORT-TERM THERAPEUTIC EFFECT OF PIRENZEPINE ON DUODENAL ULCER

将56名活动性十二指肠溃疡随机分为两纽,其中哌吡酮组35例,给予哌吡酮150mg/d,曱氰咪胍组21例,给邓甲氰眯胍800mg/d。治疗6周后内镜复查,发现溃疡愈合率分别为68.6%胍71.4%;总的有效率为82.9%及85.7%,P>0.05。止痛效果哌吡酮略优于甲氰咪胍组,但无统计学差异。哌吡酮为选择性毒蕈碱受体阻滞剂,但仍有33/35例出现不同程度度的口干,19/35例出现视力模糊,但不影响正常治疗,是可逆性的。我们认为国产哌吡酮不失为一安全有效的抗消化性溃疡新药。

Fifty-six patients with active duodenal ulcer were divided into two randomized groups: Group A(35 cases),the pirenzepine group and group B(21 cases),the cimetidine group.Pirenzepine(Domestic Product)150 mg/day were given to the group A cases.Cimetidine 800 mg/day were taken by the group B cases.The ulcer healing rates,as revealed by endoscopy done after 6-week′ treatment,were 82.9% and 85.7% respectively(P>0.05).As to the analgesic effect,p irenzepine was slightly better than cimetidine,but difference was not significant. Pirenzepine is a kind of selective muscarinic receptor blockers.Of the thirty-five cases treated by pirenzepine,thirty-three cases had dryness of the mouth of various degrees.Blurred vision occurred in nineteen cases.However,these side effects were transient and did not interfere with the normal course of the treatment.Therefore for duodenal ulcer cases,domestic pirenzepine is a drug of choice with safety and effectiveness.