多器官功能障碍综合征患者胃肠功能损伤流行病学调查

Epidemiology of Gastrointestinal Dysfunctionin in the Patients with Multiple Organ Dysfunction Syndrome in China

目的:调查国内多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS)患者胃肠功能损伤的流行病学情况。方法:采用多中心、前瞻性调查方法,分析2002年3月—2005年1月全国11省市的37家三级医院1087例MODS患者的病历资料。结果:1087例患者中,胃肠功能损伤的发生率、病死率分别为78.8%、61.7%。其中入住重症监护室(ICU)患者其28d病死率为58.9%。MODS患者胃肠功能损伤发生及死亡的高危因素分别为存在腹水、未应用或未适当应用肠内营养,用用肾上腺素等。结论:MODS患者胃肠功能损伤发生率高,其发生高危因素及死亡高危因素与腹水、肠内营养的应用等相关。患有胃肠功能损伤的MODS患者其入住ICU28d病死率较非胃肠功能损伤患者显著升高。

Objective：To investigate the epidemiology of gastrointestinal dysfunction in the patients with multiple organ dys function syndrome （MODS） in China. Methods： Prospectively collected data of 1 087 MODS patients between March 2002 and January 2005 were analysed. Patients were recruited from 37 tertiary hospitals of l 1 provinces in China. Results： The incidence and the mortality of gastrointestinal dysfunction in the MODS patients were 78. 8% and 61. 7%, repectively. The mortality within 28 days of ICU hospitalization was 58.9%. The risk factors of occurance and death included aseites, no proper intesinal nutrition, the use of epinephrine. Conclusions： MODS patients had high incidence rate of gastrointestinal dysfunction. And the MODS patients with gastrointestinal dysfunction had higher 28-day hospitalization motality than patients without it.