摘要
新烟碱类化合物主要作用于昆虫的烟碱乙酰胆碱受体(nAChRs)。概述了新烟碱类杀虫剂的结构特征,阶段性地总结了近几年基于昆虫nAChRs结构,对新烟碱类化合物的杂环部分和功能基团进行结构修饰和改造的代表性研究成果,概要介绍了这些新化合物与昆虫nAChRs之间的相互作用机制,有助于进一步探索和开发高活性的新烟碱类化合物。
Neonicotinoids act mainly on insect nicotinic acetylcholine receptors (nAChRs). The structure character of neonicotinoids is described and the typical advances on structural modification for heterocyclic and pharmacophore groups of neonicotinoids based on insect nAChRs structure in recent years are reviewed. In addition, the modes of action between new compound and insect nAChRs are summaried. It is believed that all of them would provide a theoretical help for exploring novel nicotinic compound with high activity.
出处
《农药学学报》
CAS
CSCD
北大核心
2009年第4期407-413,共7页
Chinese Journal of Pesticide Science
基金
国家自然科学基金(30800719)
中国农业大学科研启动基金(10099131)
关键词
新烟碱
烟碱乙酰胆碱受体
结构修饰
作用机制
neonicotinoids
nicotinic acetylcholine receptors ( nAChRs )
structural modification
mode of action