老年2型糖尿病患者认知功能及其与糖化血红蛋白水平的相关性研究

Correlation between Cognition Function and Level of Glycohemoglobin in Elderly with Type 2 Diabetes

目的探讨老年2型糖尿病患者认知功能水平与糖化血红蛋白水平的关系。方法选取40例老年2型糖尿病患者作为糖尿病组,并将40名年龄、性别、文化程度、职业等方面相匹配的健康人作为对照组。应用韦氏记忆量表、连线测验、威斯康星卡片分类测验法分别对两组进行认知功能检测,并将糖尿病患者的认知功能评分与糖化血红蛋白水平进行相关性分析。结果糖尿病组韦氏记忆量表各项成绩均低于对照组(P<0.01,P<0.05),连线测验完成时间较对照组明显延长(P<0.001),威斯康星卡片分类试验各项指标成绩均较对照组差(P<0.01,P<0.05)。韦氏记忆量表中长时记忆、短时记忆中联想学习及理解记忆、总记忆商与糖化血红蛋白呈负相关(r=-0.38,-0.43,-0.48,-0.46,P<0.05),威斯康星卡片分类试验中坚持性错误与糖化血红蛋白呈正相关(r=0.41,P<0.05)。结论老年2型糖尿病患者认知功能减退,且与糖化血红蛋白水平有明显的相关性。

Objective To investigate the correlation between levels of glycohemoglobin and cognitive function in elderly patients with type 2 diabetes. Methods Cognition function of 40 elderly patients with type 2 diabetes was assessed by Wechsler Memory Scale （WMS）, Trail Marking Test and Wisconsin Card Sorting Test （WCST） and was compared with 40 healthy controls matched for age, gender, education level and profession. Meanwhile, the correlation between cognition function and levels of glycohemoglobin was analyzed by regression analysis. Results The scores of Wechsler Memory Scale in the patients were lower than that in normal controls （P^0.01,P^0.05）. The patients needed much more time to complete the Trail Marking Test （P〈0. 001）. The scores of Wisconsin Card Sorting Test were significantly different between two groups （P〈0.01 ,P〈0.05）. The regression analysis showed that there was an obvious correlation between serum level of glycohemoglobin and cognition functions in patients with type 2 diabetes （r=-0. 38, -0. 43, -0. 48, 0. 46, 0. 41, P〈0. 05）. Conclusion Cognition function decreases and significantly correlates with the level of glycohemoglobin in the elderly patients with type 2 diabetes.