3种不同材质输液容器对8种药物的吸附性研究

Study on Sorption of Eight Injectable Drugs in Three Different Kinds of Intravenous Solution Containers

目的考察8种药品在3种不同材质输液容器（PVC输液袋、M312C非PVC输液袋、玻璃输液瓶）中的吸附性。方法将8种药品溶于上述3种不同材质容器的输液中,分别于混匀后的0、1、3、24、48h取样,采用高效液相色谱法测定药物浓度。结果当药物于输液中混合48h后,药物的含量与0h相比：①在PVC输液袋中,胺碘酮、氯丙嗪的含量下降至76.76%-89.84%之间;②在M312C非PVC输液袋及玻璃输液瓶中,除在水溶液中不稳定的药物外,其他药物含量下降均小于10%。结论PVC输液袋会对一些药物有吸附性,临床应避免这些药物在PVC输液袋中使用。

Objective To investigate the losses of eight injectable drugs from aqueous solutions stored in M312C Non-PVC infusion bags（NPVC）,glass bottles（G） and PVC infusion bags（PVC） respectively for 48h and compare their sorption characteristics.Methods Each drug was separately added to above infusion bags and bottles.Samples of drug solutions were collected at 0,1,3,24,48h and analyzed by HPLC methods.Results The remaining contents of amiodarone,chlorpromazine in PVC at 48h were between 76.76% and 89.84%,respectively.No significant sorption of the other drugs to the surface of G or NPVC was found（loss〈10% respectively）.Cefuroxime and ceftazidime were not stable in aqueous solutions.Conclusions PVC should be avoided to use in clinic,because of its sorption of some drugs.