新生儿败血症休克血浆内皮素水平的研究

Studies on the Plasma Endothelin in Newborn Babies with Septic Shock

本文应用放免法测定了４０例败血症休克新生儿血浆ＥＴ水平．结果表明：（１）新生儿败血症休克组血浆ＥＴ水平明显高于对照组，重度休克高于轻中度休克，死亡组高于存活组，对休克存活组１８例血浆ＥＴ水平进行动态观察，发现随着休克的纠正及病情好转，血浆ＥＴ也逐渐恢复正常．（２）Ｇ－菌感染儿血浆ＥＴ高于Ｇ＋菌感染儿．（３）休克时ＥＴ与ＢＵＮ、血Ｃｒ呈正相关，与ＰＯ２、ＢＥ呈负相关，提示ＥＴ参与新生儿败血症休克的病理生理过程，并与疾病的严重程度及预后有关．

The concentration of plasma endothelin(ET) is measured by radioimmunoassay in 40 newborn babies with septic shock. The results show that:①the values of ET are markedly increased in shock patients compared with those in control, those in bad shock with in mild, those in bad group with those still alive. By researchiny ET of 18 patients still alive,It is found that ET becomes normal step by step as shock disappears. ②ET in G - infection patients is higher than that in G + infection patients. ③In shock patients, ET is in proportion either pasitively to BUN,Cr or negtively to PO 2,BE. It indicates that ET may be involved in pathophysiological processes of newborn septic shock and is correlated with severness of disease and prognosis.