高原腹腔镜胆囊切除术对肝肾功能的影响

Effect of Laparoscopic Cholecystectomy on Human Hepatic and Renal Functi on in Plateau Region

目的探讨高原腹腔镜胆囊切除术(LC)对肝肾功能的影响,为高原地区安全开展LC提供临床依据。方法选取2007年12月—2009年3月间在我院接受LC的胆囊良性疾病74例,分别在术前1 d和术后第1、3、5、7天抽血检查肝功能指标(包括AST、ALT、TB IL)和肾功能指标(包括BUN、SC r),观察术后肝肾功能变化。结果LC后第1、3天,AST、ALT、TB IL、BUN、SC r均较术前明显升高(P<0.05),术后第5、7天,各指标逐渐恢复到正常范围,与术前比较差异不显著(P>0.05)。结论高原LC可导致患者血清AST、ALT、TB IL、BUN、SC r短暂的、可逆性增高,短期内可恢复正常,对远期肝肾功能无影响。

Objective To explore the effect of laparoscopic cholecystectomy（LC） on human hepatic and renal function in plateau region and to provide some evidence for its clinical application.Methods 74 cases of benign disease of cholecyst were treated with LC in our hospital from Dec.2007 to Mar.2009,and examined the serum levels of AST,ALT,TBIL,BUN and SCr on one day before LC,day 1,3,5 and 7 after LC respectively.Results The serum levels of AST,ALT,TBIL,BUN and SCr were significantly increased（P〈0.05） on day 1 and 3 after LC as compared with those of pre-operation,and could be reduced to normal range on day 5 and 7 after LC.Conclusion The index above mentioned could be set-up transitorily and reversibly by LC,and could be put back in short-term.So it has no effect on long-term function of hepar and kidney.