美沙拉秦缓释片治疗溃疡性结肠炎临床研究

Clinical Research of Mesalazine Slow-release Tablets on Ulcerative Colitis

目的观察美沙拉秦缓释片在溃疡性结肠炎治疗中的疗效,副作用及半年复发率。方法随机将溃疡性结肠炎患者分为治疗组40例,给美沙拉秦缓释片1 g,3次/d,复方谷胺酰氨0.2 g,3次/d餐后服用。对照组35例,给予柳氮磺胺吡啶1 g,4次/d,复方谷胺酰氨0.2g,3次/d餐后服用,均治疗至4周。而后复查肝肾功能,免疫球蛋白,血尿常规及肠镜,并继续治疗及随访半年。结果治疗组显效率为52.5.0%,总有效率为92.5%,半年复发12.5%,无明显副反应。对照组显效率为25.7%,总有效率为71.4%,半年复发率31.4%;副反应表现白细胞轻度减少4例(11.4%),胃肠道反应8例(22.8%)。结论美沙拉秦缓释片能有效治疗溃疡性结肠炎,副作用少,半年复发低。

Objective To investigate the clinical efficacy and adverse effect with the half year relapse of Mesalazine slow-release tablets on patients of ulcerative colitis.Methods 75 patients according to the admissive standard were randomly divided into the treatment group 40 cases and control group 35cases.The patients in treatment group were treated by mesalazine slow-release tablets 1.0 once,three times a day,and by goguanggantai 200 mg once,three times a day.while the patients in control group by salicylazesulfapyridine 1g once,four times a day.and by goguanggantai 200 mg once,three times a day.with a treatment course of one month for both groups,After one month and six months endoscopy was used to examine the renal function were deteceted the incidence of adverse events were recorded.Results The significant effective rate in treatment group and control group were 52.5% and 25.7% respectively,The total effective rate in treatment group and control group（92.5% and 71.4%）,while the half year relapse（12.5% and 31.4%）,there was a significant difference between the two groups（P〈0.05）.Conclusion Msalazine slow-release tablets has good treatment effect on ulcerative colitis.No adverse effect was found in treatment group,and half year relapse rate was low.