抗环瓜氨酸肽抗体及类风湿因子对诊断类风湿关节炎的意义

Diagnostic Value of Anti-cyclic Citrullinated Peptide Antibody and Rheumatoid Factor in Rheumatoid Arthritis

目的评价抗环瓜氨酸肽抗体(抗CCP抗体)在类风湿关节炎(RA)诊断中的意义。方法收集临床确诊的80例RA患者、56例非RA自免病患者和126例健康体检者的血样标本,同时以ELISA法检测抗CCP抗体,以散射比浊法检测类风湿因子IgM-RF。结果IgM-RF和抗CCP抗体诊断RA的敏感性分别为78.75%和67.75%,抗CCP抗体和RF诊断RA的特异性分别为97.62%和65.85%。抗CCP抗体和lgM-RF两者均阳性诊断RA的特异性(99.20%)高于单独检测IgM-RF(P<0.05)。结论抗CCP抗体、RF均是RA良好的血清学诊断指标,两者有相关性,联合检测可提高RA诊断的准确性。

Objective To examine the diagnostic value of anti-cyclic citrullinated peptide（anti-CCP） antibody in rheumatoid arthritis.Methods Blood samples were collected from 80 Rheumatoid arthritis（RA） patients,56 non-RA patients and 1 26 health adult,Anti-CCP antibody was detected by enzyme-linked immunosorbent assay,Rheumatoid factor（RF）was detected by nephelometry.Results IgM,the sensitivity of RF and anti-CCP antibody Was 78.75%and 67.75%respectively.The specificity of RF and anti-CCP antibody Was 65.85%and 97.62%respectively.When anti-CCP antibody and RF were positive at the sametim.it had a high specificity（99.20%）in RA.Conclusion Anti-CCP antibody and RF are two satisfactory serum markers for RA and there is a correlation between them.The combination of anti-CCP antibody and RF can raise the diagnostic accuracy.