复方丹参注射液和黄芪注射液治疗肺源性心脏病急性发作期并心力衰竭的疗效观察

Observation on therapeutic efficacy of composite salvia miltiorrhiza injection and astragalus injection on corpulmonale during acute phase complicated by heart failure

目的：观察复方丹参注射液加黄芪注射液治疗肺源性心脏病（肺心病）急性发作期并心力衰竭（心衰）的疗效。方法：９５例肺心病急性发作期并心衰患者随机分为２组。对照组４４例给予休息、低盐饮食、低流量持续吸氧、保持呼吸道通畅、抗感染、止咳祛痰平喘、强心、利尿等综合治疗；治疗组５１例在对照组治疗基础上静滴复方丹参注射液和黄芪注射液。２组患者于治疗后２周测定血液流变学指标并进行疗效判断。结果：治疗组治疗后血液流变学各项指标均有显著性改善（Ｐ均＜０．０１），且优于对照组。治疗组和对照组治疗后临床总有效率分别为９２．１６％和７２．７３％，经统计学处理有显著性差异（χ２＝１０．８６，Ｐ＜０．０１）。２组均无不良反应。结论：肺心病急性发作期并心衰加用复方丹参注射液和黄芪注射液治疗效果显著，用药安全。

Objective:To observe the therapeutic efficacy of composite salvia miltiorrhiza injection and astragalus injection on corpulmonale during acute phase complicated by heart failure.Methods:Ninetyfive cases of corpulmonale during acute phase complicated by heart failure were divided randomly into 2 groups.The control group (44 cases) was treated with bed rest,low salt diet,constant oxygen inhalation,keep respiratory tract from impeding,antiinfection,ease cough,reduce phlegm,cardiotonic,diuretic etc;the treatment group (51 cases) was treated with composite salvie miltiorrhiza injection and astragalus injection for intravenous drip on the basis of control group therapy method,then,to detect the hemorrheologic parameters and to evaluate the therapeutic efficacy after treatment for 2 weeks.Results:In treatment group,the hemorrheologic parameters were improved obviously (all P <0 01),it was superior to that in control group.The total effective rates were 92 16% and 72 73% in treatment group and control group respectively,it was obvious difference between 2 groups (χ 2=10 86, P <0 01)and no sideeffects in 2 groups.Conclusions:There are better effectiveness and safeness of composite salvia miltiorrhiza injection and astragalus injection in treatment of corpulmonale during acute phase complicated heart failure.