“龙参汤”合肝素治疗重度慢性阻塞性肺气肿并发弥散性血管内凝血疗效观察

Observation on therapeutic efficacy of Longshen Decoction plus heparin on severe chronic obstructive emphysem complicated disseminated intravascular coagulation

目的：观察“龙参汤”合肝素治疗重度慢性阻塞性肺气肿并发弥散性血管内凝血（ＤＩＣ）的临床疗效。方法：６０例患者随机分为２组（各３０例）。２组患者均予常规综合治疗，对照组加用肝素治疗；治疗组则在对照组治疗基础上加用“龙参汤”。结果：治疗组和对照组临床总有效率分别为９６．６７％和８０．００％，２组比较有显著性差异（χ２＝４．０４３，Ｐ＜０．０５）；２组患者治疗后出凝血指标、动脉血气指标及血液流变性均有明显改善，治疗组又好于对照组。结论：“龙参汤”合肝素治疗重度慢性阻塞性肺气肿并发ＤＩＣ疗效更明显。

Objective:To observe the therapeutic efficacy of Longshen Decoction(龙参汤) combined use of heparin on severe chronic obstructive emphysem (COE) complicated by disseminated intravascular coagulation (DIC).Methods:Sixty patients were divided randomly into 2 groups,they were treated with same conventional therapy.In addition,the control group (30 cases) was treated with heparin,while treatment group (30 cases) was treated with Longshen Decoction on the basis of control group therapy method.Results:The total effective rates were 96 67% and 80 00% in treatment group and control group respectively,there was obvious difference between 2 groups (χ 2=4 043, P <0 05).At the same time,the blood coagulation index,arterial blood gas analysis and hemorrheologic parameters were improved obviously after therapy in 2 groups patients,while the efficacy in treatment group was superior to control group.Conclusions:There are obvious efficacy of Longshen Decoction combined use of heparin in treatment of severe COE complicated by DIC,so it is worth to study deeply.