国产舒喘灵溶液雾化吸入在急性哮喘发作期治疗中的作用

THE EFFICACY OF DOMESTIC SULBUTAMOL SOLUTION IN TREATMENT OF ACUTE ASTHMA BY SPRAY INHALATION

目的：观察国产舒喘灵溶液和进口喘乐宁溶液雾化治疗疗效。方法：１６０例哮喘急性发作期患者，其中舒喘灵组８３例，喘乐宁组７７例，分别雾化吸入国产舒喘灵溶液和进口喘乐宁溶液２．５ｍｇ。结果：吸入国产舒喘灵溶液后ＦＥＶ１从５ｍｉｎ即显示增加，１ｈ左右达高峰（从（１．１６±０．４５）Ｌ升至（１．５５±０．５８）Ｌ，Ｐ＜０．０５），并可持续４ｈ。与进口喘乐宁溶液比较，两组患者在临床疗效、肺功能改善及副反应的发生率方面均无显著性差异。结论：舒喘灵溶液雾化吸入疗效确实。

OBJECTIVE:To compare the efficacy of domestic and imported salbutamol solution in treatment of acute asthma by spray inhalation.METHODS:The study was conducted in 160 patients with acute asthma among them,77 were allocated to domestic salbutamol solution and 83 were allocated to imported ventolin,in a dose of 2.5 mg given by aerosol inhalation.RESULTS:The FEV 1 of domestic salbutamol group increased significantly after 5 min dosing and reached maximal at 1 h and lasted for 4 h.No significant differences between groups in efficacy;improvement in lung function and ADRs were observed.CONCLUSION:Domestic salbutamol solution administered by aerosol inhalation is as effective as imported one in treatment of asthma acute attack.