盐敏感性高血压与第16号染色体短臂串联重复序列β ENaCGT-1遗传相关性研究

Genetic Association of Salt Sensitive Hypertension with Polymorphism of Short Tandem Sequence in Human Chromosome 16p β ENaCGT 1

采用变性聚丙烯酰胺凝胶电泳及硝酸银染色技术分析了βＥＮａＣＧＴ１的扩增长度片段多态性与盐敏感性高血压间遗传相关性。结果，在盐敏感性高血压人群中Ｓ１Ｓ４基因型明显降低，Ｓ３Ｓ４基因型明显增高，关联分析显示Ｓ１Ｓ４与盐敏感性高血压呈负相关（ＲＲ＝０２９），Ｓ３Ｓ４与盐敏感性高血压呈正相关（ＲＲ＝７５２）。这一结果提示，在βＥＮａＣＧＴ１位点所在的１６ｐ１２～ｐ１３染色体区域可能存在盐敏感性高血压的易感基因。

In this paper,the genetic association of salt sensitive hypertension with polymorphism of βENaCGT 1 was analyzed.The results showed that the βENaCGT 1 loci Amp FLP were associated with salt sensitive hypertension.Compared the frequencies of βENaCGT 1 loci Amp FLP in groups of SS,NSS and controls,the phenotype S1 S2 was decreased significantly(χ 2=8 25,P<0 01)in patients with salt sensitive hypertension,and S3 S4 phenotype was increased significantly in SS group(χ 2=4 36,P<0 05).The association study showed that there was a positive association between SS and S3 S4 phenotype(RR=7 52),therefor the S1 S2 phenotype negative association with SS was found (RR=0 29).These results suggested that there may be some genes that related to salt sensitive hypertension in βENaCGT 1 loci 16p12 p13.