2型糖尿病视网膜病变与血浆内皮素的相关分析

Study of relationship between the plasma leves ET and the diabetic microangiopathy in type 2 diabetes mellitus

目的探讨糖尿病视网膜病变与血浆内皮素的关系及临床意义。方法55例2型糖尿病患者作为研究对象,分为糖尿病视网膜病变组28例,无视网膜病变组27例,30例健康体检者为正常对照组,采用放射免疫法检测血浆内皮素指标的含量。结果2型糖尿病患者血浆内皮素水平明显高于对照组(P<0.01),且视网膜病变组明显高于无视网膜病变组(P<0.05)。结论2型糖尿病患者血浆内皮素水平明显高于对照组,提示2型糖尿病微血管变之前已有广泛的内皮功能受损,内皮素与视网膜病变的程度密切相关。

Objective To study the relationship between the plasma leves ET and diabetic microangiopathy and conclude the clinical importance. Methods 55 cases with type 2 diabetes were selected randomly and divided in to two groups .One was 28 cases With microangiopathy. The other was 27 cases without microangiopathy. The conrtol group was 30 cases healthy subjects, Using the method of radio-immtmity, the leves of ET in plasma was measured in all subjects. Results The results showed that leves of ET was higher （P〈0.01） in type microangiopathy group and without microangiopathy group. Conclusions The leves of ET was signfifcantly different between the microangiopathy and others.They were good indexes between ET and the degree in mlcoanglopathy.