强心苷的抗肿瘤治疗研究进展

Advances in research on anticancer effects of cardiac glycosides

强心苷类药物是临床治疗心力衰竭和心房颤动的常用药物。近年的研究发现,强心苷能够抑制人类肿瘤细胞的增殖以及诱导肿瘤细胞凋亡,其作用靶点涉及抑制Na+/K+-ATP酶和缺氧诱导因子-1α的表达,因而具有抗肿瘤治疗的潜能。本文介绍了强心苷与肿瘤治疗相关的药理学特点及其研究进展。

Efficacy of cardiac glycosides in treatment of congestive heart failure and atrial fibrillation is well appreciated. New findings have revealed that these compounds can significantly inhibit proliferation of human tumor cells as well as induce apoptosis. Some evidences support the hypothesis that the action targets of these compounds involve inhibition of expression of Na^＋ ,K^＋ -ATPase and hypoxia inducible factor-1α（ HIF- 1α）, therefore,they have potential ability to inhibit human tumors. This review focuses on recent advances in research on pharmacology of cardiac glycosides as potential therapy of human cancers.