不稳定型心绞痛患者介入治疗后超敏C反应蛋白与预后的关系

Changes of high sensitivity C-reactive protein of unstable angina pectoris after percutaneous coronary intervention

目的探讨不稳定型心绞痛(UAP)患者介入治疗后超敏C反应蛋白(hs-CRP)的变化,并评估其对患者预后的影响。方法对符合条件的158例行经皮冠脉介入治疗(PCI)的UAP患者(UAP组)和91例冠状动脉造影正常患者(对照组),采用双抗体夹心法检测术前、术后24h血清hs-CRP的变化;并对UAP患者进行术后1年随访,以评价术后24h血清hs-CRP水平与首次发生主要心血管病事件的关系。结果UAP组术后24h血清hs-CRP浓度与术前的差值高于对照组[(1.08±0.89)mg/L∶(0.36±0.29)mg/L,t=7.483,P=0.000];PCI术后血清hs-CRP≥3.0 mg/L的UAP患者1年内首次主要心血管病事件的发生率高于hs-CRP<3.0 mg/L者(2χ=1.267,P=0.260)。结论PCI术后24h血清hs-CRP水平是影响UAP患者1年内首次发生主要心血管病事件的一个重要因素。

Objective To study the changes of high sensitivity e-reactive protein （hs-CRP） of unstable angina pectoris （UAP） after pereutaneous coronary intervention （PCD and evaluate the affection of hs-CRP for UAP＇s prognosis. Methods The serum hs-CRP before operation and 24h after operation was detected by sandwich immunodetection method in 158 cases with UAP（UAP group） with PCI and 91 cases with normal coronary arteriongraphy （control group）. The relationship was appreciated between the serum levels of hs-CRP 24h after operation and the first time happening major cardiovascular events in follow-up visit of a year. Results The difference of serum levels of hs-CRP with before operation and 24h after operation of UAP patients were higher than the control group. The incidence of first time of major cardio- vascular events of patients with UAP after one year of PCI for UAP group（hs-CRP≥3.0 mg/L）were higher than the control group（hs-CRP 〈3.0 mg/L）（χ^2 =1. 267,P=0. 260）. Conclusion The serum levels of hs-CRP of 24h after PCI were the important factor affecting the first time of major cardiovascular events of patients with UAP.