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老年晚期胃癌患者FOLFOX4方案治疗的观察护理 被引量:2

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摘要 目的观察FOLFOX 4方案对老年晚期胃癌的近期疗效及毒副反应,探讨针对性的护理措施。方法对23例采用FOLFOX 4方案治疗的老年晚期胃癌患者进行观察护理,在治疗4个周期后评价疗效及不良反应。结果全组23例,总有效率为43.5%,10例初治病例有效率为50.0%,13例复治病例有效率为38.5%。全组总体生活质量改善率为30.4%,初治患者为40.0%,复治者为23.1%。不良反应以恶心、呕吐最常见,多为Ⅰ度反应,有2例Ⅲ度反应;严重的血液学毒性少,仅2例出现Ⅲ度粒细胞减少;Ⅰ度末梢神经毒性反应亦常见,有1例Ⅱ度反应,无Ⅲ度反应发生。结论FOLFOX 4方案是一高效低毒治疗老年晚期胃癌的化疗方案,应采取针对性护理措施,保证治疗的顺利完成和减少不良反应,让老年患者易于耐受,达到更好疗效。
出处 《西部医学》 2010年第1期180-182,共3页 Medical Journal of West China
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  • 1Goldberg R, Sargent DJ, Morton RF, et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer [J]. J Clin Oncol, 2004,22 (1):23-30.
  • 2Cheeseman S, Joel S, Chester J, et al. A "modified de gramont" regimen of fluorouracil, alone and with oxaliplatin,for advanced colorectal cancer [J]. Brit J Cancer, 2002,87:393-399.
  • 3Douillard J, Cunning, ham D, Roth A, et al. Irinotecan combined with fluorouraeil compared with fluorouraeil alone as first-line treatment for metastatic colorectal cancer:a muhicentre randomised trial [J]. The Lancet, 2000,355: 1041-1047.
  • 4Andre T, Louvet C, Maindrault-Goebel F, et al. CPT-11(irinotecan) addition to bimonthly, high-dose leucovorin and bolus and continous-infusion 5-fluorouracil (FOLFIRI) for pretreated metastatic colorectal cancer [J]. Eur J Cancer, 1999,35(9): 1343-1347.
  • 5Maindrauh-Groebel F, Lledo G, Chibaudel B, et al.OPTIMOX2, a large randomized phase Ⅱ study of maintenance therapy or chemotherapy-free interval (CF1) after FOLFOX in patients with metastatic colorectal cancer (MRC). A GERCOR study[J]. 2006 ASCO Annual Meeting Proceedings, Abstract 3504.

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