六君子汤合玉屏风散治疗婴幼儿哮喘并反复呼吸道感染疗效观察

Efficacy of Liujunzi Decoction combined with Yupingfeng Powder in infant asthma with recurrent respiratory infection

目的观察六君子汤合玉屏风散治疗婴幼儿哮喘并反复呼吸道感染的疗效。方法61例婴幼儿哮喘并反复呼吸道感染患儿随机分为西医组31例和中西医结合组30例。西医组给予布地奈德气雾剂吸入治疗,中西医结合组在此基础上缓解期加用六君子汤合玉屏风散治疗。随访1年,观察呼吸道感染次数和哮喘发作次数,并行免疫功能检查。结果中西医结合组呼吸道感染次数和哮喘发作次数分别为(4.53±1.59)次/年和(1.53±0.97)次/年,西医组为(6.87±1.48)次/年和(2.48±1.06)次/年;中西医结合组血清IgG、IgA浓度,CD3、CD4细胞亚群及CD4/CD8明显高于西医组,而CD8亚群低于西医组。两组比较差异均有统计意义(P<0.05或P<0.01)。结论六君子汤合玉屏风散用于婴幼儿哮喘并反复呼吸道感染缓解期患儿可减少呼吸道感染次数和哮喘发作次数,并改善其免疫功能。

Objective To observe the efficacy of Liujunzi Decoction combined with Yupingfeng Powder in infant asthma with recurrent respiratory infection （RRI）. Methods 61 children with infant asthma and RRI were divided randomly into two groups. Simple Western medication group （31 cases） were treated with inhaled budisonide. Traditional Chinese medicine （TCM） combined with Western medicine group （30 cases） were given Liujunzi Decoction combined with Yupingfeng Powder in remission stage on the basis of inhaled budisonide. Incidence of RRI and wheeze was recorded and immunity function was detected during one year follow-up. Results The number of infective episodes and wheeze was （4. 53 ± 1. 59 ） times/year and （ 1.53 ± 0.97） times/year in TCM combined with Western medicine group, （ 6.87 ± 1.48 ） times/year and （2.48 ± 1.06） times/year in simple Western medication group. There were higher serum concentration of IgG and IgA, CD3, CD4 T cells and CD4/CD8 and lower CDs T cells in TCM combined with Western medicine group. Compared to simple Western medication group, there was all significant difference between two groups. Conclusion Liujunzi Decoction combined with Yupingfeng Powder can decrease the number of infective episodes and wheeze, and improve immunity function.