胃癌及其癌旁病变γ-GT和粘液组织化学研究

HISTOCHEMICAL RESEARCH ON γ-GT AND MUCUS IN GASTRIC CARCINOMA AND LESIONS NEAR CARCINOMA

对49例新鲜切除的胃标本(胃癌41例,非癌8例)进行γ-GT和AB/PAS、HID粘液组织化学研究。结果:胃癌γ-GT阳性率为65.9%,其阳性率和阳性强度与胃癌的分化程度以及肠型粘液分泌关系密切。在化生肠上皮中,γ-GT的阳性率达90%,阳性的出现与化生的不同类型没有明显的关系,但其阳性分布形式与高分化腺癌相关。在癌旁异型增生上皮中,γ-GT也呈高阳性率出现。因此,γ-GT不仅是胃癌也是癌前期病变的有价值的指标。

We have made γ-glutamyltransferase (γ-GT), AB/PAS (pH2.5), and HID mucous histochemical research on 49 freshly excised stomach samples (41 of gastric carcinoma and 8 of non-carcinomatous disease). The results show that the positive rates of γ-GT in gastric carcinoma are high (65.9%). The positive rate and intensity are correlated with differentiated extent and intestinal mucus secretion. In intestinal metaplasia epithelium the positive rates are 90%, there is no significant difference between positive rates and different types of metaplasia. But the distribution is correlated with high differentiated adenocarcinoma. In the dysplasia epithelium near carcinoma,there appear highly positive rates of γ-GT. Thus, γ-GT is a valuable index not only in gastric carcinoma but in precarcinomatous lesions.