铝碳酸镁对胆汁反流性胃炎疗效及胃内24小时胆汁的影响

Effect of hydrotalcid on bile reflux gastritis and 24 hour intragastric bile

目的探讨铝碳酸镁对胆汁反流性胃炎疗效及胃内２４小时胆汁的影响。方法１０例胆汁反流性胃炎，均经２４小时胃内胆汁监测证实，其中５例为胃大部切除术后毕氏Ⅱ式吻合患者。铝碳酸镁１０ｇ，每日４次，治疗１周后观察腹痛、反酸、恶心、呕吐胆汁等症状变化，并复查２４小时胃内胆汁监测。结果治疗后患者上述症状均明显减轻（Ｐ值＜００１），总有效率为９／１０。２４小时胃内胆汁反流总时间百分比由治疗前２０７６％±１３３２％降至４９３％±４５９％（Ｐ值＜００１），反流次数由７３６±４３６降至３４５±１５２（Ｐ值＜００５）。结论铝碳酸镁可结合胃内胆汁，为治疗胆汁反流性胃炎的有效药物。

Objective To evaluate the effect of hydrotalcid on bile reflux gastritis and 24 hour intragastric bile. Methods The severity of the symptoms including abdominal pain, regurgitation, nausea and vomiting of bile were investigated before and one week after treatment by hydrotalcid 1.0 g four times one day in 10 patients with bile reflux gastritis proven by intragastric 24 hour bile monitoring, including 5 patients with Billroth Ⅱ gastrectomy. Intragastric 24 hour bile monitoring was also reexamined. Results The severity of all the four symptoms greatly decreased after treatment ( P <0.05). The total fraction time of bile reflux decreased from 20.76%±13 32% to 4.93%±4.59% ( P <0.01), and the number of bile reflux decreased from 73.6±43.6 to 34.5±15 2 ( P <0.05). Conclusion Hydrotalcid can combine intragastric bile and is effective on bile reflux gastritis.