糖尿病视网膜病变与红细胞胰岛素酶活性的关系

Relationship between insulinase activity of erythrocytes and diabetic retinopathy

目的探讨非胰岛素依赖型糖尿病（ｎｏｎ－ｉｎｓｕｌｉｎ－ｄｅｐｅｎｄｅｎｔｄｉａｂｅｔｅｓｍｅｌｉｔｕｓ，ＮＩＤＤＭ）患者糖尿病视网膜病变（ｄｉａｂｅｔｉｃｒｅｔｉｎｏｐａｔｈｙ，ＤＲ）与红细胞胰岛素酶活性（ｉｎｓｕｌｉｎａｓｅａｃｔｉｖｉｔｙｏｆｅｒｙｔｈｒｏｃｙｔｅｓ，ＥＩＡ）的关系。方法对有ＤＲ的ＮＩＤＤＭ患者４２例，无ＤＲ的ＮＩＤＤＭ患者４４例以及正常对照者５５例，分别检测ＥＩＡ、空腹血糖（ｆａｓｔｉｎｇｐｌａｓｍａｇｌｕｃｏｓｅ，ＦＰＧ）、空腹血浆胰岛素（ｆａｓｔｉｎｇｐｌａｓｍａｉｎｓｕｌｉｎ，ＦＩＮＳ）及糖基化血红蛋白（ｇｌｙｃｏｓｙｌａｔｅｄｈｅｍｏｇｌｏｂｉｎ，ＨｂＡ１ｃ）。结果有ＤＲ的ＮＩＤＤＭ患者ＥＩＡ为（６９４．５４±１２６．８４）ｐｍｏｌ·ｓ－１·ｇ－１，无ＤＲ的ＮＩＤＤＭ患者ＥＩＡ为（８２８．８０±１０７．３１）ｐｍｏｌ·ｓ－１·ｇ－１；有ＤＲ的ＮＩＤＤＭ患者病程更长，ＦＰＧ、ＨｂＡ１ｃ更高（Ｐ值均小于０．０５）。在ＤＲ患者中，增殖型ＤＲ患者ＥＩＡ为（６３７．８８±１３５．５９）ｐｍｏｌ·ｓ－１·ｇ－１，单纯型ＤＲ患者ＥＩＡ为（７３１．２２±１１８．９３）ｐｍｏｌ·ｓ－１·ｇ－１（?

Objective To study the relationship between insulinase activity of erythrocytes(EIA)and diabetic retinopathy(DR) in non insulin dependent diabetes mellitus (NIDDM) patients. Methods EIA,fasting plasma glucose (FPG),fasting plasma insulin (FINS) and glycosylated hemoglobin (HbA 1c) were determined in 55 healthy controls,42 NIDDM patients with DR and 44 NIDDM patients without DR. Results EIA was lower,disease duration was longer,and FPG and HbA 1c were higher in NIDDM patients with DR.EIA was decreased,duration of NIDDM was lengthened,FPG and HbA 1c were increased in NIDDM patients with proliferative DR as compared with NIDDM patients with background DR.The correlation analysis showed,in NIDDM patients with DR,EIA was inversely correlated with FPG,HbA 1c and duration of NIDDM. Conclusion Insulinase may play certain role in the onset and development of DR.