厚朴麻黄口服液治疗支气管哮喘的临床与实验研究

Clinical and Experimental Study on the Houpu Mahuang Oral Liquid in Treating Bronchial Asthma

目的 :探讨厚朴麻黄口服液治疗支气管哮喘的疗效及作用机理。方法 :测定支气管哮喘患者服用厚朴麻黄口服液前后的肺功能和血清IgE变化情况。动物实验观察其抗过敏及解痉作用。结果 :厚朴麻黄口服液不仅可以改善临床症状 (P <0 0 5)和肺功能 (P <0 0 5) ,使异常升高的IgE下降 (P <0 0 1 ) ,而且具有显著抑制大鼠被动皮肤过敏反应及解痉作用。结论 :厚朴麻黄口服液具有解痉、抗过敏、抗变态反应作用 。

objective To probe into the curative effect and mechanism of action of the Houpu Mahuang oral liquid (HPMH) in treating bronchial asthma. Methods: The pulmonary function and level of serum IgE of the patients were determined before and after HPMH treatment. The anti allergic reaction and relieving spasm effect of HPMH in animal were also observed. Results: HPMH is not only effective in improving clinical symptoms and pulmonary function (P<0 05), so as to lower the abnormal raising of IgE (P<0 01), but also has a notable inhibitory effect for passive allergic reaction of rat′s skin, it can relieve spasm. Conclusions: HPMH is effective in relieving spasm, antiallergic reaction, it can improve the symptoms of bronchial asthma.