前列腺方治疗慢性前列腺炎血瘀证的临床与实验研究

Study on Treatment of Blood Stasis Syndrome of Chronic Prostatitis Using Prostatitis Decoction and its Extract Capsule

目的 :验证前列腺方 (汤剂及胶囊 )的临床疗效及作用机理。方法 :用前列腺汤剂和前列腺胶囊分别治疗慢性前列腺炎血瘀证 32 2例和 2 39例患者 ,并与用前列康片治疗的95例作对照 ,观察治疗前后前列腺液 (EPS) pH值及锌 (EPS Zn)含量 ,并进行动物血液流变学及微循环观察。结果 :汤剂组、胶囊组和对照组临床治愈率分别为 6 5 8%、54 4 %和 1 7 9% ;汤剂可明显改善EPS pH和EPS Zn含量。实验研究结果表明前列腺方有降低实验性家兔血瘀模型的全血粘度、血小板粘附率、体外血栓干重 ;对肾上腺素引起的小鼠微循环障碍模型的微动脉血流停止或减慢有显著推迟发生作用。结论 :前列腺方 (汤剂及胶囊 )

Objective: To test and verify the effects of prostatitis decoction and its capsule on the treatment of chronic prostatitis with blood stasis Syndrome, and its therapeutic mechanism. Methods: Five hundred and sixty one Patients were treated for 2 months, decoction group 322 cases, and capsule group 239 cases. As control group, 95 cases were treated with Qianliekang tablets. Expressed prostatic secretion(EPS) pH and Zn content were measured before and after treatment. Observation on hemorheology and microcirculation disturbance with animal experiments were conducted. Results: The cure rate of Prostatitis decoction and capsule groups was 65.8%, and 54.4% respectively, that of control group was only 17.9%. EPS pH and Zn were markedly improved after Prostatitis decoction treatment. Experimental work revealed that Prostatitis decoction and its capsule had lowered the whole blood viscosity, thrombocyte adhesiveness rate and dry weight of thrombus in blood stasis rabbit model; and on rats model of microcirculation disturbance caused by adrenalin, the Prostatitis decoction and its capsules had obviously delayed the occurrence of reduction and stopping of blood flow in arterioles. Conclusion: Prostatitis decoction (capsule) was effective in treating chronic prostatitis.