参麦注射液对大鼠5/6肾切除模型肾脏及腹膜形态结构的影响

Effect of Shenmai Injection on Morphological Structure of Kidney and Peritoneum in Rats with 5/6 Nephrectomy

目的 :探讨参麦注射液对 5/ 6肾切除大鼠肾脏和腹膜的保护作用。方法 :通过5/ 6肾切除造成大鼠肾功能衰竭模型 ,使用细胞形态计量学中体密度 (Vv) ,平均截面积 (A) ,面数密度 (NA)等参数及光学和电子显微镜观测参麦注射液腹腔、肌肉用药后大鼠腹膜及肾脏形态结构的变化。结果 :参麦注射液具有减轻肾小球的纤维化程度 ,促进受损的腹膜间皮细胞修复和再生的作用 ,对腹膜的保护作用以腹腔用药较显著。结论 :参麦注射液具有保护 5/

Objective: To study the protective effect of Shenmai injection (SMI) on kidney and peritoneum in rats with 5/6 nephrectomy. Methods: By using cell morphological quantification, light microscopy and scanning electron microscopy, the morphological structure changes of peritoneum and kidney in rats with 5/6 nephrectomy caused chronic renal failure model after the intramuscular or intraperitoneal injection of SMI were observed. Results: The SMI injection could relieve glomerular sclerosis, promote the recovery and proliferation of injured peritoneal mesothelial cell. The effect of the SMI intraperitoneal injection is better than that intramuscular of injection. Conclusion: The SMI has the protective effect on kidney and peritoneum in rats with 5/6 nephrectomy.