血尿酸与2型糖尿病患者下肢血管病变的关系

The Associativity of Blood Uric Acid and Lower Extremity Vascular Disease in Type 2 Diabetic

目的:探讨血尿酸(UA)水平与2型糖尿病(T2DM)患者下肢血管病变是否有关。方法:本研究选择T2DM患者240例,全部受试者均采用高分辨彩色多普勒超声检查判定下肢动脉病变程度,按下肢血管病变严重程度进行评分,所有入选病例分为T2DM下肢血管病变组与非病变组,比较病变组与非病变组间血UA水平是否有差异;同时根据血UA水平又分为高UA水平组和正常UA水平组,分析两组患者的下肢血管病变发生率及病变严重程度情况。结果:糖尿病下肢血管病变组血UA水平显著高于非病变组(P<0.05),而糖尿病高血UA组较正常血UA组的下肢血管病变发生率显著增加,病变程度更重(P<0.05)。结论:血UA是T2DM下肢血管病变的危险因素。

Objective：To investigate the associativity of blood uric acid and lower extremity vascular disease in type 2 diabetic.Methods：in this research,we selected 240 paitents who were diagnosed type 2 diabetes mellitus.All of them received high-resolution color Doppler ultrasonography of lower extremity arteries to evaluate if they had vaxcular disease in the lower extremities and their pathological change degress.According to the degress,we scored for vascular disease in the lower extremities and divided all patients into group-positive group and negative group,to compare the level of blood uric acid between the two groups is identical or not;at the same time According to level of blood uric acid divided all patients into hight-group and nornal-group,Compare the prevalence and the process severity of vascular disease in the lower extremities.Result：The finding show that the level of blood uric acid of group-positive group is significantly higher than the level of negative group（P〈0.05）.Compare the hight-group to the nornal-group,the prevalence of vascular disease in the lower extremities is increased statistically and the process severity is advanced （P〈0.05）.Coneclusions：Blood uric acid was the significant risk factor of vascular disease in the lower extremities in type 2 diabetic patients.