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转化生长因子β诱导的上皮间质化与头颈部鳞状细胞癌 被引量：1

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摘要 上皮间质化（epithelial mesenchymal transition，EMT）作为肿瘤侵袭转移的演变过程，以上皮特性丧失和间质特性获得为主要特征。转化生长因子β（transforming growth factor beta，TGF—β）作为一有效诱导物，在肿瘤侵袭转移中有重要影响。本文就EMT及其诱导物TGF—β在肿瘤侵袭转移中的作用做一综述。
作者 朱卉 于振坤
机构地区 首都医科大学附属北京同仁医院 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科
出处 《国际耳鼻咽喉头颈外科杂志》 2010年第1期4-6,共3页 International Journal of Otolaryngology-Head and Neck Surgery
关键词 转化生长因子Β 上皮间质 头颈部鳞状细胞癌 肿瘤侵袭转移 诱导物 TGF EMT
分类号 R739.91 [医药卫生—肿瘤]
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  • 1Greenburg G, Hay ED. Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J Cell Biol, 1982,95:333-339.
  • 2Boyer B, Valles AM, Edme N. Induction and regulation of epithelialmesenchymal transitions. Biochem Pharmacol, 2000, 60. 1091-1099.
  • 3Thiery JP. Epithelial-mesenchymal transition in tumor progression.Nature Rev Cancer, 2002,2:442-454.
  • 4Tepass U, Truong K, Godt D, et al. Cadherins in embryonic and neural morphogenesis. Nature Rev Mol Cell Biol, 2000,1:91 -100.
  • 5Foty RA, Steinberg MS. Cadherin-mediated cell-cell adhesion and tissue segregation in relation to malignancy, lnt J Dev Biol, 2004,48 :397 - 409.
  • 6Kang Y, Massague J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell, 2004,118:277-279.
  • 7Savagner P. Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition. Bioessays, 2001,23:912 - 923.
  • 8Thiery JP. Epithelial-mesenchymal transition in development and pathologies. Curr Opin Cell Biol, 2003,15:740-746.
  • 9Vernon AE, LaBonne C. Tumor Metastasis: A new twist on Epithelial-mesenchymal transitions. Curr Biol, 2004,14:719 - 721.
  • 10Fujita Y, Krause G, Scheffner M, et al. Hakai, a c-Cb1-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol, 2002,4:222 -231.

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  • 1Al - Hajj M, Wicha MS, Benito - Hernandez A, et al. Prospective identication of tumorigenic breast cancer cells [J]. Proe Natl Acad Sci USA, 2003, 100(7) : 3983 -3988.
  • 2Sheridan C, Kishimoto H, Fuchs RK, et al. CD44 +/CD24 - breast cancer cells exhibit enhanced invasive properties an early step nee- essary form etastasis [ J ]. Breast Cancer Res,2006,8 ( 5 ) : R59.
  • 3Mumcuoglu M, Bagislar S, Yuzugullu H, et al. The ability to generate senescent progeny as a mechanism underlying breast cancer cell heterogeneity [ J ]. PLoS One,2010,5 ( 6 ) :e11288.
  • 4Balic M, Linl H, Young L, et al. Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a puta- tive breast cancer stem cell phenotype [ J ]. Clin Cancer Res, 2006,12(19) : 5615.
  • 5Hirschmann - Jax C, Foster AE, Wulf GG, et al. A distinct " side population" of cells with high drug efflux capacity in human tumor cells[J]. Proc Natl Acad Sci USA,2004, 101 (39): 14228 - 14233.
  • 6Chang C, Li X, Wong H, et al. Therapeutic resistance and tumor initiation :molecular pathways involved in breast cancer stem cell self- renewal [ J]. J Clin Oncol, 2007, ASCO Ann Meeting Pro- ceed,2007,25(18S) :528 -540.
  • 7Shipitsin M, Lauren L, Polyak K, et al. Molecular definition of breast tumor heterogeneity [ J ] . Cancer Cell, 2007,11 (3) :259.
  • 8Mylona E, Giannopoulou I, Fasomytakis E, et al. The clinicopath- ologic and prognostic significance of CD44^+/CD24^-/ low and CD44^-/CD24^+ tumor cells in invasive breast carcinomas [ J ]. Hum Pathol, 2008, 39 (7) : 1096.
  • 9Ginestier C, Hur MH, Charafe - Jauffret E,et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome [ J]. Cell Stem Gell, 2007, 1 (5) :555.
  • 10Lee RC, Eeinbaum RL, Ambros V. The Celegans heterochronic gene lin -4 encodes small RNAs with antisense complementarity tolin-14 [J]. Cell.1993,75(5): 843 -854.

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国际耳鼻咽喉头颈外科杂志
2010年 第1期

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