白介素23及其受体的致炎机能

Inflammation function of interleukin-23 and interleukin-23 receptor

白介素23（IL-23）是-个由IL-23p19和IL-12p40组成的异二聚体细胞因子，属IL—12炎症因子家族成员。它广泛参与体内免疫过程，调节免疫细胞的分化发育、增殖及炎症反应。1L-23受体复合物由IL-12R[31和IL-23R两个亚基构成。IL-23受体的致病作用与通过IL-23-信号转导和转录激活因子3-Th17-IL-17途径介导免疫异常有关。在治疗慢性炎症方面，以IL-23配体或受体为靶点的单克隆抗体已取得初步成效。对IL-23／IL-23受体基因及其致病途径的深入研究。将为寻找更多慢性炎症治疗的靶点提供有力依据。随着先进的分子生物学以及其他技术的应用，对IL-23／IL-23受体的作用将会有更多更深入的认识，为-些相关疾病的发病机制和治疗手段的研究提供理论基础。

Interleukin-23（IL-23） is a member of IL-12 family,a heterodimer composed of IL-23p19 and IL-12p40. It extensively participates in immunologic process in vivo, regulates differentiation, proliferation and inflammatory reaction of immunocyte. IL-23 receptor compound is composed of IL-12Rβ1 and IL-23R. The pathogenic mechanism of IL-23 receptor to inflammation is associated with the disordered immune response mediated by IL-23-signal transducer and activators of transcription-3 helper T cell-17- IL-17 pathway. Monoclonal antibodies targeting to the ligands or receptors of IL-23 have been prospective in the biotherapy of inflammation. Further study on the IL-23/IL-23 receptor genes and their functions in the pathogenesis of inflammation will help us find more treatment targets. With advanced molecular biology and other technology, more and more recognition of IL-23/IL- 23 receptor will appear, which can provide rationale to pathogenesy and treatment of correlated diseases.