摘要
毒素一抗毒素系统（TAs）广泛存在于非严格胞内寄生的细菌等原核生物中，基因的多态性分析表明，它们具有共同的祖先。目前已经对TAs多个家族进行了蛋白晶体结构解析，并且分析了它们作用的方式。TAs由于具有RNA酶的活性并且能够在特定的mRNA碱基排列位置切割mRNA，因此TAs在细菌的潜伏感染与适应环境刺激等方面发挥了重要作用。进一步对目前严重危害人类的结核分枝杆菌的全基因组分析表明：结核分枝杆菌存在36对TAs基因，目前已经有少量TAs的功能在结核分枝杆菌中得到证明。
Members of toxin-antitoxin system （TAs）are abundant in free-living prokaryotes and virtually absent from obligate host-associated organisms. Gene polymorphism analysis has shown that they have a common ancestor. The protein crystal structure and mode of action of TAs have been analyzed. TAs proteins have the activity of RNA enzymes and could cut mRNA in the particular location of mRNA bases, so they play an important role in dormant infection of bacteria and acclimationas stimulus. Further studies on the Myeobacterium tuberculosis genome-wide have shown that Mycobacterium tubereulosis has as much as 36 pairs of TAs loci,and only small numbers of TAs have been demonstrated.
出处
《国际呼吸杂志》
2010年第2期108-111,共4页
International Journal of Respiration
