呼吸系统疾患血浆纤维结合蛋白含量检测意义

OBSERVATION OF THERAPEUTIC EFFECTS OF RETINOIC ACID ON ADULT ACUTE PROMYELOCYTIC LEUKEMIA

用火箭电泳法对110例呼吸系统疾患进行了血浆Fn测定。93例次肺部疾患血浆Fn均低于正常人,其中白细胞计数≥10×10~9/L和中性粒细胞>80%者降低明显;40例胸部疾患血浆Fn和胸水Fn改变不显著。同时对其机理进行了讨论。指出血浆Fn测定对肺部疾患合并感染的诊断和监测有一定临床意义。

The therapeutic effects of retinoic acid (RA), a differentiation-inducing agent, on acute promyelocytic leukemia were preliminarily observed, and compared with those of HOAP chemotherapy regimen. The complete remissaiol rates were respectively 89% (8/9 patients) and 20% (3/15 patients) in group RA and group HOAP. The death rate during period in hospital was 0% in group RA versus 73.3% in group HOAP. There were significant differences between the two groups. The average amount of blood transfusion in group RA was also greatly lower than that in group HOAP. The chemotherapy with HOAP often initiated or aggravated DIC, severe thrombocytopenia and leucopenia, which were important causes of early death, but the treatment with RA had none of these serious results. We believe that RA is evidently superior to traditional cytotoxic drugs in the treatment of acute promyelocytic leukemia.