摘要
用大剂量地塞米松治疗D-氨基半乳糖诱发的大鼠急性肝坏死,发现不管肝坏死早、晚期给药均不能提高其生存率,改变转氨酶、肝组织病理、血和脑氨基酸谱型,但地塞米松使正常大鼠肝细胞出现明显浊肿,为此建议对大剂量地塞米松的应用要慎重。
Administering high dose of dexamethasone to rats in the early or late stage of acute hepatic failure (AHF) induced by D-galactosamine, no beneficial effect was found on survival, serum aminotransferase, hepatic histopathology, and blood and brain amino acid patterns, but obvious hepatocellular cloudy swelling was presented in normal rats treated with dexamethasone. It was suggested that administering high dose of dexamethasone to treat AHF should be careful.
出处
《南通医学院学报》
1990年第4期271-274,348,共4页
ACTA Academiae Medicinae Nantong
关键词
肝坏死
地塞米松
转氨酶
生存率
acute hepatic failure
dexamethasone
survival rates
aminotransferase
hepatic histopathology
amino acids
