大型超临界CO_2流体萃取装置的设计与开发

Design and Development of A Large-scale CO_2 SCFE Plant

超临界CO_2流体萃取技术已广泛应用于天然产物的提取,成为中药现代化的关键技术之一,在中药新药的开发及中药生产中获得了成功的应用,并取得了良好的效果。本文主要报道了大型中药超临界CO_2流体萃取装置的设计与开发,着重讨论了超临界CO_2流体萃取装置中关键设备提取、分离容器的设计要点以及工业化装置开发应用过程中要解决的问题。设计与开发的大型超临界CO_2萃取装置已广泛应用于天然产物的提取及中药生产中。

The CO2 SCFE technology is an efficient method to extract natural products. As a primary technology for the traditional Chinese medicine （TCM） modernization, it has been widely used in the development of new TCM and the TCM production. This article introduces the design and development of a large-scale CO2 SCFE plant for the TCM, especially focusing on the critical design requirements of the key equipment in such a plant, the extraction/separation vessels, and the problems to be solved during its development and application.