摘要
目的探讨大肠癌患者血清白细胞介素-8(IL-8)水平及其临床意义。方法采用酶联免疫吸附试验(ELISA)检测80例大肠癌患者术前、术后血清IL-8水平,并以50例健康者作为对照组。结果大肠癌患者术前、术后血清IL-8水平均高于对照组,差异有统计学意义(P<0.01);术前大肠癌患者血清IL-8水平高于术后,差异有统计学意义(P<0.05);随着Duke′s分期的深入,大肠癌患者血清IL-8水平也逐步升高,差异有统计学意义(P<0.01)。结论血清IL-8水平与大肠癌的发生、发展及预后有关联,与Duke′s分期显著相关,可作为大肠癌术后随访观察及判断预后的指标之一。
Objective To investigate the level of serum IL -8 in the patients with colorectal cancer and its clinical significance. Methods To compare the level of serum IL- 8 before and after operation in 80 patients with colorectal cancer by using enzyme-linked immunosorbent assay （ELISA） method with 50 cases as normal contral. Results The level of serum IL-8 in the patients with colorectal cancer before and after operation were significantly higher than that in normal groups （P〈0. 01）. The level of serum IL-8 before operalion were significantly higher lhan that after operation （P〈0.05）. With deepening of the Duke＇s staging,the serum IL-8 levels in the patients with colorectal cancer also gradually increased with significant difference （P〈0.01）. Conclusion The levels of serum IL-8 is associated with colorectal cancer＇s occurrence,development and prognosis,and significantly correlaled with Duke＇s stages, which can be one of indicators to carry out follow-up observation of colorectal cancer and judge the prognosis.
出处
《检验医学与临床》
CAS
2010年第1期36-37,共2页
Laboratory Medicine and Clinic
关键词
大肠肿瘤
白细胞介素-8
酶联免疫吸附试验
eolorectal neoplasms
interleukin- 8
enzyme linked immunosorbent assay
