口服布洛芬佐治新生儿硬肿症临床观察

Clinical observation of oral Ibuprofen in the treatment of neonatal scleredemas

目的:探讨口服布洛芬治疗新生儿硬肿症的疗效。方法:45例新生儿硬肿症根据治疗药物的不同分为治疗组和对照组,两组患儿均积极采取保暖、抗感染、供给足够热卡和液体、维持重要脏器功能正常等综合治疗,治疗组25例加用布洛芬佐治,10mg/kg,至硬肿症消退后停药;对照组20例加用肝素30～50U/kg治疗。结果:治疗组显效率(76%)较对照组(45%)增加,组间有显著性差异(P<0.05);治疗组的总有效率为88%,对照组为90%,组间无显著性差异(P>0.05)。结论:口服布洛芬治疗新生儿硬肿症安全有效,无明显消化道出血及肺出血等不良反应,用量易掌握,对凝血相血浆凝血酶原时间(PT)及活化部分凝血活酶时间(APTT)无明显影响,有临床推广价值。

Objective： To study the effect of oral Ibuprofen in the treatment of neonatal scleredemas. Methods： 45 cases of neonatal scleredemas were allocated to the treatment group and the control group according to different medicine treatment. Both group had the same treatments such as recovery of temperature, prevention of infection, reasonable provision of calory and liquid, maintain the normal functions of important organs. 25 cases of the treatment group received additional oral Ibuprofen （10 mg/kg） until scleredemas disappearing. 20 cases of the control group received Heparin treatment （30-50 U/kg）. Results： The significant efficiency of the treatemt group （76%） was more than the control group （45%） and had remarkable difference （P〈0.05）. The total effective rate in the treatment group and the control group was 88% and 90%, there was no significant difference （P〉0.05）. Conclusion： Oral Ibuprofen in the treatment of neonatal scleredemas was safe and effective, and has fewer side effects such as gastrointestinal haemorrhage or pulmonary haemorrhage. Its dosage is easily to control and has no effection in coagulation （PT or APTT）. It has clinical value.