葡萄胎患者化疗前后SIL-2R和TNF含量检测的临床意义

Studies on Clinical Value of Determination of SIL－2R and TNF Levels in Patients with Hydatidiform Mole

分析了32例葡萄胎患者化疗前后血清中SIL－2R和TNF含量的变化。结果表明:化疗前血清中SlL－2R和TNF含量均显著地高于正常对照组（P＜0.01，P＜0.001），化疗后均有明显的下降（P＜0.05），SIL－2R和TNF与β－HCG呈正相关（r=0.6263，r＝0.6105，P＜0.01）。机理不明。结果提示：血清SIL－2R和TNF可作为葡萄胎患者免疫功能监测指标之一，并可作为疗效判断的参考。

During pre－and post chemotherapy SIL－2R and TNF were analyzed in 32 patients with hydatidiform mole. The result showed that prechemotherapy SIL－2R and TNF levels in the patients were higher than those in the controls (P < 0. 01, P< 0. 001 ), post chemotherapy SIL－2R and TNF levels were decreased. (P < 0. 05 ). β－HCG had a positive correlationship with SIL－2R and TNF(r = 0. 6263, r = 0. 6105, P < 0. 01 ), but the mechanism of their correlationship is not clear at present. The results here suggest that the detection of serum level of SIL－2R and TNF might be a useful method of monitoring the immune function in patients with hydatidiform mole.